A Case of Multiple Endocrine Neoplasia 2B with Probable Ectopic Adrenocorticotropic Hormone-Secreting Liver Metastasis from Medullary Thyroid Carcinoma
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چکیده
منابع مشابه
Medullary Thyroid Carcinoma with Ectopic Adrenocorticotropic Hormone Syndrome
Ectopic adrenocorticotropic hormone (ACTH) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare etiology of ectopic ACTH syndrome. We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48-year-old male. He was diagnosed with MTC 14 years ago and underwent total thyroidectomy, cer...
متن کاملMultiple endocrine neoplasia, type 2B, with medullary thyroid carcinoma: a diagnostic potential for dentistry.
Multiple endocrine neoplasia (MEN) Type 2B is designation that has been proposed for the combination of medullary thyroid carcinoma (MTC), parathyroid adenoma, pheochromocytoma, mucosal neuromas, and somatic abnormalities. ~ The neural lesions produced a characteristic diffuse or nodular involvement of the tongue, lips, and buccal mucosa. Because of these multiple neuromas on the mucosal surfac...
متن کاملEctopic Cushing's syndrome due to CRH secreting liver metastasis in a patient with medullary thyroid carcinoma.
Ectopic production of CRH by a medullary thyroid carcinoma or its metastases is a rare cause of ectopic Cushing's syndrome (ECS). We report a 45-year old male with medullary thyroid carcinoma (MTC), who, 24 years following the initial diagnosis, presented with clinical and biochemical evidence of an ACTH dependent Cushing's syndrome. Rapid deterioration of his clinical condition and elevated co...
متن کاملVandetanib in children and adolescents with multiple endocrine neoplasia type 2B associated medullary thyroid carcinoma.
PURPOSE Medullary thyroid carcinoma (MTC) is a manifestation of multiple endocrine neoplasia type 2 (MEN2) syndromes caused by germline, activating mutations in the RET (REarranged during Transfection) proto-oncogene. Vandetanib, a VEGF and EGF receptor inhibitor, blocks RET tyrosine kinase activity and is active in adults with hereditary MTC. EXPERIMENTAL DESIGN We conducted a phase I/II tri...
متن کاملSimultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic m...
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ژورنال
عنوان ژورنال: Journal of UOEH
سال: 2013
ISSN: 0387-821X
DOI: 10.7888/juoeh.35.193